Kara, my son does have reflux and is on Zantac. I am hopeful the spitting up will get better though. This morning he took half his 6 oz bottle, pulled away, burped and spit up, then refused to take anymore. The only time he takes a bottle without a fuss or spitting up is at BT and during the night. It is a real challenge, but I am just going with him and feeding him when he acts hungry which is no sooner than every 4hrs. I just don't understand why he won't take a full bottle during the day anymore. My doctor wants to switch him to a different and stronger medication for reflux. I am not sure these issues are related to his reflux though.