Hi there bless him and you sounds tough.
Definitely not the cry it out method, we don’t support that here and it will break the trust he has in you.
Has he just turned 3 if so it could coincide with developmental regressions that happen at birthdays and half birthdays.
I personally would try some walk in walk out just to reassure him you’re there, must be very unnerving for him having a needle to deal with until he gets used to it more x