My little guy was on nutramigen and now neocate. There was a slight improvement with neocate, but we needed to find the right combo of formula and meds. Once we started him on prevacid AND neocate, we saw a decent change. He still spits up a TON, but it's better than it used to be. Since nothing really made him totally comfortable (it seemed that every change made him better for 2 weeks, then he went back to being uncomfortable and puking again), we started to see a chiropractor and that helped a lot, too. Just a thought if nothing else is working!